The effect of fibres and carbonation conditions on the mechanical properties and microstructure of lime/flax composites

Fibre and textile-reinforced mortars are increasingly being used for a variety of building applications, including the strengthening of masonry structures. Lime mortars reinforced with sustainable fibres (such as vegetable or cellulosic fibres) may provide an interesting solution. In this paper, a mixture of commercial lime with 20% metakaolin addition was used to produce composites reinforced with non-woven flax fabrics that were cured at different moisture contents (from 0 to 100%) for 7 or 14 days in a CO2 incubator. The composites were char- acterised to determine their flexural behaviour, carbonation level and microstructure. According to the results, no differences exist in the flexural strength of the composites made in the moisture range of 33%–66%. At 7 days of curing, they attained Modulus of Rupture (MOR) values that exceeded 5.5. MPa. Moreover, it was observed that under high moisture conditions, the permeability of the fibres allows for CO2 access, despite the saturation of the pores of the matrix – allowing a reaction in the vicinity of the fibres –, while under dry conditions, the fibre’s moisture retention does not permit the carbonation of the matrix in their vicinity, even though complete carbonation takes place after 14 daysPostprint (published version

A techno-economic study of optical network disaggregation employing Open-Source Software business models for Metropolitan Area Networks

This work provides a techno-economic evaluation of optical disaggregation architectures in the context of metropolitan area networks. The study compares two optical disaggregation options (partial vs. total) against the legacy benchmark where optical equipment is subject to vendor lock-in, as it is deployed in most networks today. We show that emerging open source software projects within the software-defined networking ecosystem can potentially yield significant cost savings for medium- and large-size network operators, while they can introduce extra flexibility and agility to network operations and service deployments.This work has been supported by EU H2020 project Metro-Haul, grant no. 761727 (https://metro-haul.eu)

Experimental evaluation of a dynamic PCE-based regenerator-efficient IA-RWA algorithm in translucent WSON

We devise a novel dynamic PCE-based impairment-aware RWA algorithm in translucent GMPLS WSON that minimizes regenerator usage. Experimental evaluation carried out on the Open GMPLS/PCE control plane of CTTC ADRENALINE test-bed shows that significant improvements (>340%) are attained in terms of the offered traffic load.Peer ReviewedPostprint (published version

Enabling data analytics and machine learning for 5G services within disaggregated multi-layer transport networks

Recent advances, related to the concepts of Artificial Intelligence (AI) and Machine Learning (ML) and with applications across multiple technology domains, have gathered significant attention due, in particular, to the overall performance improvement of such automated systems when compared to methods relying on human operation. Consequently, using AI/ML for managing, operating and optimizing transport networks is increasingly seen as a potential opportunity targeting, notably, large and complex environments.Such AI-assisted automated network operation is expected to facilitate innovation in multiple aspects related to the control and management of future optical networks and is a promising milestone in the evolution towards autonomous networks, where networks self-adjust parameters such as transceiver configuration.To accomplish this goal, current network control, management and orchestration systems need to enable the application of AI/ML techniques. It is arguable that Software-Defined Networking (SDN) principles, favouring centralized control deployments, featured application programming interfaces and the development of a related application ecosystem are well positioned to facilitate the progressive introduction of such techniques, starting, notably, in allowing efficient and massive monitoring and data collection.In this paper, we present the control, orchestration and management architecture designed to allow the automatic deployment of 5G services (such as ETSI NFV network services) across metropolitan networks, conceived to interface 5G access networks with elastic core optical networks at multi Tb/s. This network segment, referred to as Metro-haul, is composed of infrastructure nodes that encompass networking, storage and processing resources, which are in turn interconnected by open and disaggregated optical networks. In particular, we detail subsystems like the Monitoring and Data Analytics or the in-operation planning backend that extend current SDN based network control to account for new use cases.Peer ReviewedPostprint (author's final draft

Laboratorio E3PACS de investigación en micro-redes

En este trabajo se presenta el nuevo laboratorio E3PACS de investigación en micro-redes, sus características y equipamientos. Dicho laboratorio se encuentra situado en el edificio A de la (EEBE), en el nuevo campus Diagonal-Besòs de la Universitat Politècnica de Catalunya (UPC), un campus con reconocimiento de excelencia internacional en energía. A lo largo del presente trabajo, se dará a conocer a la comunidad científica el estado del citado nuevo laboratorio de altas prestaciones, desarrollado durante los últimos dos años y medio y financiado totalmente con fondos públicos.Peer ReviewedPostprint (published version

A control and management architecture supporting autonomic NFV services

The proposed control, orchestration and management (COM) architecture is presented from a high-level point of view; it enables the dynamic provisioning of services such as network data connectivity or generic network slicing instances based on virtual network functions (VNF). The COM is based on Software Defined Networking (SDN) principles and is hierarchical, with a dedicated controller per technology domain. Along with the SDN control plane for the provisioning of connectivity, an ETSI NFV management and orchestration system is responsible for the instantiation of Network Services, understood in this context as interconnected VNFs. A key, novel component of the COM architecture is the monitoring and data analytics (MDA) system, able to collect monitoring data from the network, datacenters and applications which outputs can be used to proactively reconfigure resources thus adapting to future conditions, like load or degradations. To illustrate the COM architecture, a use case of a Content Delivery Network service taking advantage of the MDA ability to collect and deliver monitoring data is experimentally demonstrated.Peer ReviewedPostprint (author's final draft

IDEALIST control and service management solutions for dynamic and adaptive flexi-grid DWDM networks

Personal use of this material is permitted. Permission from IEEE must be obtained for all other uses, in any current or future media, including reprinting/republishing this material for advertising or promotional purposes, creating new collective works, for resale or redistribution to servers or lists, or reuse of any copyrighted component of this work in other works. R. Muñoz, V. López, R. Casellas, O. González de Dios, F. Cugini, N. Sambo, A. d'Errico, O. Gerstel, D. King, S. López-Buedo, P. Layec, A. Cimmino, R. Martínez, and R. Moro, "IDEALIST control and service management solutions for dynamic and adaptive flexi-grid DWDM networks", in Future Network and Mobile Summit, 2013, pp. 1-10Wavelength Switched Optical Networks (WSON) were designed with the premise that all channels in a network have the same spectrum needs, based on the ITU-T DWDM grid. However, this rigid grid-based approach is not adapted to the spectrum requirements of the signals that are best candidates for long-reach transmission and high-speed data rates of 400Gbps and beyond. An innovative approach is to evolve the fixed DWDM grid to a flexible grid, in which the optical spectrum is partitioned into fixed-sized spectrum slices. This allows facilitating the required amount of optical bandwidth and spectrum for an elastic optical connection to be dynamically and adaptively allocated by assigning the necessary number of slices of spectrum. The ICT IDEALIST project will provide the architectural design, protocol specification, implementation, evaluation and standardization of a control plane and a network and service management system. This architecture and tools are necessary to introduce dynamicity, elasticity and adaptation in flexi-grid DWDM networks. This paper provides an overview of the objectives, framework, functional requirements and use cases of the elastic control plane and the adaptive network and service management system targeted in the ICT IDEALIST project.This work was partially funded by the European Community’s Seventh Framework Programme FP7/2007-2013 through the Integrated Project (IP) IDEALIST under grant agreement nº 317999

Beta-blocker treatment of patients with atrial fibrillation attenuates spontaneous calcium release-induced electrical activity

Aims Atrial fibrillation (AF) has been associated with excessive spontaneous calcium release, linked to cyclic AMP (cAMP)-dependent phosphorylation of calcium regulatory proteins. Because ß-blockers are expected to attenuate cAMP-dependent signaling, we aimed to examine whether the treatment of patients with ß-blockers affected the incidence of spontaneous calcium release events or transient inward currents (ITI). Methods The impact of treatment with commonly used ß-blockers was analyzed in human atrial myocytes from 371 patients using patch-clamp technique, confocal calcium imaging or immunofluorescent labeling. Data were analyzed using multivariate regression analysis taking into account potentially confounding effects of relevant clinical factors Results The L-type calcium current (ICa) density was diminished significantly in patients with chronic but not paroxysmal AF and the treatment of patients with ß-blockers did not affect ICa density in any group. By contrast, the ITI frequency was elevated in patients with either paroxysmal or chronic AF that did not receive treatment, and ß-blocker treatment reduced the frequency to levels observed in patients without AF. Confocal calcium imaging showed that ß-blocker treatment also reduced the calcium spark frequency in patients with AF to levels observed in those without AF. Furthermore, phosphorylation of the ryanodine receptor (RyR2) at Ser-2808 and phospholamban at Ser-16 was significantly lower in patients with AF that received ß-blockers. Conclusion Together, our findings demonstrate that ß-blocker treatment may be of therapeutic utility to prevent spontaneous calcium release-induced atrial electrical activity; especially in patients with a history of paroxysmal AF displaying preserved ICa density.Peer ReviewedPostprint (published version

Laboratorio E3PACS de investigación en micro–redes

En este trabajo se presenta el nuevo laboratorio E3PACS de investigación en micro-redes, sus características y equipamientos. Dicho laboratorio se encuentra situado en el edificio A de la Escola d’Enginyeria de Barcelona Est (EEBE), en el nuevo campus Diagonal-Besòs de la Universitat Politècnica de Catalunya (UPC), un campus con reconocimiento de excelencia internacional en energía. A lo largo del presente trabajo, se dará a conocer a la comunidad científica el estado del citado nuevo laboratorio de altas prestaciones, desarrollado durante los últimos dos años y medio y financiado totalmente con fondos públicos.Postprint (published version

The SARS-CoV-2 Ivermectin Navarra-ISGlobal Trial (SAINT) to Evaluate the Potential of Ivermectin to Reduce COVID-19 Transmission in low risk, non-severe COVID-19 patients in the first 48 hours after symptoms onset: A structured summary of a study protocol for a randomized control pilot trial

Objectives: The primary objective is to determine the efficacy of a single dose of ivermectin, administered to low risk, non-severe COVID-19 patients in the first 48 hours after symptom onset to reduce the proportion of patients with detectable SARS-CoV-2 RNA by Polymerase Chain Reaction (PCR) test from nasopharyngeal swab at day 7 post-treatment